Publications
Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells
Researchers find that Vitamin C improves the speed and efficiency of mouse iPSC generation.
Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease
Scientists examine the challenges and assumptions in creating a disease model from a single cell of a patient.
Direct cell reprogramming is a stochastic process amenable to acceleration
Scientists demonstrate that reprogramming by transcription factors is a continuous stochastic process where almost all mouse donor cells eventually give rise to iPS cells on continued growth and transcription factor expression.
In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles.
Scientists suggest further investigation into the potential of nanoparticles to migrate into the uterus, placenta and embryo and their possible effects on embryogenesis.
Designing materials to direct stem-cell fate
Researchers suggest cell biological and biomaterials technologies to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.
Systems-level dynamic analyses of fate change in murine embryonic stem cells
Researchers present a dynamic systems-level study of cell fate change in murine ESCs following a well-defined perturbation.
Direct cell reprogramming is a stochastic process amenable to acceleration
Scientists demonstrate that reprogramming by transcription factors is a continuous stochastic process where almost all mouse donor cells eventually give rise to iPS cells on continued growth and transcription factor expression.
Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors
Data suggests potential mechanisms that may influence lineage commitment and hESC maintenance at the level of specific splice isoforms and microRNA regulation.
A Robust and Highly Efficient Immune Cell Reprogramming System
Researchers describe a lineage reprogramming system consisting of a B cell line with an estradiol-inducible form of C/EBPα where cells can be converted into macrophage-like cells at 100% efficiency within 2 to 3 days.
The Egfr-Sox2-Egfr Feed-Back Loop Positively Regulates the Self-Renewal of Neural Precursor Cells
Scientists conclude that NPC self-renewal is enhanced through a novel cellular feed-back loop with mutual regulation of Egfr and Sox2.





