Stemolecule™ BIO
BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.1
1. Sato, N. et al., Nat Med 10:1, 55–63 (2004).
1. Sato, N. et al., Nat Med 10:1, 55–63 (2004).
Stemolecule™ BIO
BIO (6-bromoindirubin-3'-oxime) is a potent, reversible and ATP-competitive inhibitor for GSK-3a/β in the Wnt signaling pathway. BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells1.
References
- Sato, N. et al., Nat Med 10:1, 55-63 (2004).
For research use only. Not for use in diagnostic procedures. Not for resale.
Stemolecule™ BIO
| Alternate Name | Indirubin |
| Synonym | (2'Z,3'E)-5-Bromoindirubin-3'-oxime |
| Chemical Formula | C16H10BrN3O2 |
| Structure |
![[structure graphics]](http://commerce.stemgent.com/products/04-0003/images/structure.gif)
|
| Molecular Weight | 356.17 |
| CAS Number | 667463-62-9 |
| PubChem Substance ID | 24724412 |
| Purity | >98% by HPLC analysis |
| Formulation | Dark red solid |
| Solubility | Soluble in DMSO (100 mM) or ethanol (10 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 561 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%. |
| Storage | 4°C protected from light. Following reconstitution, store aliquots at -20°C |
| Stability | Stock solutions stable at -20°C for 6 months |
| Quality Control | The purity of BIO was determined by HPLC analysis. The accurate mass and structure of BIO was determined by mass spectrometry and NMR, respectively. Cellular toxicity of BIO was tested by using HeLa and HEK293 cells |
| References |
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