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Stemgent offers advanced stem cell-qualified reagents and
tools developed by some of the world's leading stem cell scientists.
Stemolecule™ CHIR99021
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Product Overview
The aminopyrimidine CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β (GSK3β) reported to date1, 2. Unlike alsterpaullone, kenpaullone, SB214763, and SB415286 that are potent inhibitors of GSK-3, CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3β compared to CDKs with a Ki of <10 nM in vitro3.
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References
- Ring D. B. et al., Diabetes, 52:588-595 (2003).
- Hall R. K. et al., J Biol Chem, 275:30169-30175 (2000).
- Finlay D. et al., BMC Molecular Biology, 5:15.
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Chemical Formula |
C22H18Cl2N8
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| Structure |
![[structure graphics]](http://commerce.stemgent.com/products/04-0004/images/structure.gif)
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| Molecular Weight |
465.34
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| Purity |
>95% by HPLC analysis
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| Formulation |
Off-white solid
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 430 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
4°C protected from light. Following reconstitution, store aliquots at -20°C
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| Stability |
Stock solutions stable at -20°C for 6 months
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| Quality Control |
The purity of CHIR99021 was determined by HPLC analysis. The accurate mass and structure of CHIR99021was determined by mass spectrometry and NMR, respectively. Cellular toxicity of CHIR99021 was tested by using HeLa and HEK293 cells.
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Technical Documents
Specifications
MSDS
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