Spec Sheet

Stemolecule™ PD0325901

Catalog #	Size	Price (USD)	Quantity
04-0006	2 mg	$239.00	Qty:

PD0325901 selectively binds and inhibits MEK, which may result in the inhibition of the phosphorelation and activation of MAPK/ERK.^1,2

1. Bain, J. et al., Biochem. J. 408:297-315 (2007).
2. Sebolt-Leopold, J. S. ∓ Herrera, R. Nature Rev. Cancer 4:937-947 (2004).

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Stemolecule™ PD0325901

PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation^1,2.

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References

Bain, J. et al., Biochem. J. 408:297-315 (2007).
Sebolt-Leopold, J. S. ∓ Herrera, R. Nature Rev. Cancer 4:937-947 (2004).
Tongxiang Lin, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek & Sheng Ding. (2009) A chemical platform for improved induction of human iPSCs. Nat Meth 1393.

For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ PD0325901

Chemical Formula	C₁₆H₁₄F₃IN₂O₄
Structure
Molecular Weight	482.19
Purity	>98% by HPLC analysis
Formulation	Pale purple solid
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 415 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability	Stock solutions stable at -20°C for 6 months
Quality Control	The purity of PD0325901 was determined by HPLC analysis. The accurate mass and structure of PD0325901 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD0325901 was tested by using HeLa and HEK293 cells.
References	Bain, J. et al., Biochem. J. 408:297-315 (2007). Sebolt-Leopold, J. S. ∓ Herrera, R. Nature Rev. Cancer 4:937-947 (2004). Tongxiang Lin, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek & Sheng Ding. (2009) A chemical platform for improved induction of human iPSCs. Nat Meth 1393.