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Product Overview
Sodium butyrate is the sodium salt of the short-chain fatty acid butyric acid1. Butyrate is a metabolite of intestinal bacteria and a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract2. The effects of sodium butyrate on cell volume regulation and chloride transport in the rat distal colon were first described by M. Diener et al. in 19973. Sodium butyrate is a known inhibitor of histone deacetylases4,5. The enhancement and suppression of various cytokines in stimulated human monocytes using sodium butyrate was first reported in 20002. In cultured mouse and human cells, sodium butyrate has been shown to inhibit both the mRNA and protein level of cyclin D16.
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References
- Kolthoff, I. M. et al., Quantitative Chemical Analysis, 4th ed., MacMillan Pub. (New York, NY: 1969).
- Saemann, M. D. et al., FASEB J., 14(15):2380-2382 (2000).
- Diener, M., and Scharrer, E., Biochem. Physiol. A Physiol., 118(2):375-379 (1997).
- Kruh, J., Mol. Cell. Biochem. ,42(2):65-82 (1982).
- Ware C.B., Wang L., Mecham B.H., Shen L., Nelson A.M., Bar M., Lamba D.A., Dauphin D.S., Buckingham B., Askari B., Lim R., Tewari M., Gartler S.M., Issa J.P., Pavlidis P., Duan Z., Blau C.A. (2009) Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 4(4):359-69.
- Lallemand, F. et al., Biochem. Biophys. Res. Commun., 229(1):163-169 (1996).
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Chemical Formula |
C4H7NaO2
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| Structure |
![[structure graphics]](http://commerce.stemgent.com/products/04-0005/images/structure.png)
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| Molecular Weight |
111.1
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| CAS Number |
156-54-7
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| PubChem Substance ID |
24891873
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| Purity |
>98% by titration
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| Formulation |
White solid
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 4500 µl of DMSO to 5 mg of compound. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
4°C protected from light. Following reconstitution, store aliquots at -20°C
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| Stability |
Stock solutions stable at -20°C for 6 months
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| Quality Control |
The purity of sodium butyrate was determined by HPLC analysis. The accurate mass and structure of sodium butyrate was determined by mass spectrometry and NMR, respectively. Cellular toxicity of sodium butyrate was tested by using HeLa and HEK293 cells.
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Technical Documents
Specifications
MSDS
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