Spec Sheet

Stemolecule™ PD173074

Catalog #	Size	Price (USD)	Quantity
04-0008	2 mg	$119.00	Qty:

PD173074 inhibits the FGF signaling pathway.

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Stemolecule™ PD173074 chemical structure.

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Stemolecule™ PD173074

Stemolecule™ PD173074 is a potent, cell-permeable and ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor¹. Inhibition of the FGF signaling pathway leads to self-renewal of stem cells in many systems. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 significantly decreased their clonogenicity and differentiation potential². Also, differentiation of mouse embryonic stem (ES) cells requires auto-inductive stimulation of the mitogen-activated protein kinase pathway by FGF4^3,4 including autocrine FGF4⁵.

References

Mohammadi, M. et al., EMBO J. 17:5896-5904 (1998).
Zaragosi, L. E. et al., Stem Cells 24:2412-2419 (2006).
Kunath, T. et al., Development 134:2895-2902 (2007).
Stavridis, M. et al., Development 134:2889-2894 (2007).

For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ PD173074

Chemical Formula	C₂₈H₄₁N₇O₃
Alternate Name	1-t-Butyl-3-(6-(3,5- dimethoxyphenyl)-2- (4-diethylaminobutylamino)- pyrido[2,3-d]pyrimidin- 7-yl)urea
Structure
Molecular Weight	523.7
CAS Number	219580-11-7
Purity	>98.8% by HPLC analysis
Formulation	Yellow solid
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 382 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	4°C protected from light. Following reconstitution, store aliquots at -20°C
Stability	Stock solutions stable at -20°C for 6 months
Quality Control	The purity of PD173074 was determined by HPLC analysis. The accurate mass and structure of PD173074 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD173074 was tested by using HeLa and HEK293 cells.
References	Mohammadi, M. et al., EMBO J. 17:5896-5904 (1998). Zaragosi, L. E. et al., Stem Cells 24:2412-2419 (2006). Kunath, T. et al., Development 134:2895-2902 (2007). Stavridis, M. et al., Development 134:2889-2894 (2007).