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Stemolecule™ PD173074
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Product Overview
Stemolecule™ PD173074 is a potent, cell-permeable and ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor1. Inhibition of the FGF signaling pathway leads to self-renewal of stem cells in many systems. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 significantly decreased their clonogenicity and differentiation potential2. Also, differentiation of mouse embryonic stem (ES) cells requires auto-inductive stimulation of the mitogen-activated protein kinase pathway by FGF43,4 including autocrine FGF45.
References
- Mohammadi, M. et al., EMBO J. 17:5896-5904 (1998).
- Zaragosi, L. E. et al., Stem Cells 24:2412-2419 (2006).
- Kunath, T. et al., Development 134:2895-2902 (2007).
- Stavridis, M. et al., Development 134:2889-2894 (2007).
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Chemical Formula |
C28H41N7O3
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| Alternate Name |
1-t-Butyl-3-(6-(3,5- dimethoxyphenyl)-2- (4-diethylaminobutylamino)- pyrido[2,3-d]pyrimidin- 7-yl)urea
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| Structure |
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| Molecular Weight |
523.7
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| CAS Number |
219580-11-7
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| Purity |
>98.8% by HPLC analysis
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| Formulation |
Yellow solid
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 382 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
4°C protected from light. Following reconstitution, store aliquots at -20°C
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| Stability |
Stock solutions stable at -20°C for 6 months
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| Quality Control |
The purity of PD173074 was determined by HPLC analysis. The accurate mass and structure of PD173074 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of PD173074 was tested by using HeLa and HEK293 cells.
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Technical Documents
Specifications
MSDS
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