Stemolecule™ (-)-Indolactam V

Stemolecule™ (-)-Indolactam V

Stemolecule™ (-)-Indolactam V is an inhibitor of protein kinase C (PKC) isozymes (alpha, beta-I, beta-II, gamma, delta, epsilon, eta, theta)¹. PKC isozymes play a crucial role in cellular signal transduction via the second messenger, 1,2-diacyl-sn-glycerol (DG)¹. Indolactam was identified in a high-content chemical screen as a small molecule inducer of human embryonic stem cell differentiation to functional insulin-secreting beta cells at the definitive endoderm cell stage thereby increasing the number of Pdx1-expressing pancreatic progenitor cells².

References

1. Irie, K., Nakagawa, Y., Ohigashi, H. (2004) Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Curr Pharm Des 10: 1371-85.
2. Chen, S., Borowiak, M., Fox, J.L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L.F., Schreiber, S.L., Rubin, L.L., Melton, D. (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 5: 258-65.

For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ (-)-Indolactam V

Size / Quantity	300 μg
Alternate Name	Indolactam
CAS Number	90365-57-4
Chemical Formula	C17H23N3O2
Structure
Formulation	White to off-white solid
Molecular Weight	301.38
Purity	≥ 95%
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 100 µl of DMSO to the entire contents of the vial.
Storage	Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Stability	Stock solutions stable at -20°C for 6 months.
Quality Control	The purity of (-)-Indolactam V was determined by HPLC analysis. The accurate mass of Indolactam was determined by mass spectrometry. Cellular toxicity of Indolactam was tested on mouse embryonic stem cells.
References	Irie, K., Nakagawa, Y., Ohigashi, H. (2004) Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Curr Pharm Des 10: 1371-85. Chen, S., Borowiak, M., Fox, J.L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L.F., Schreiber, S.L., Rubin, L.L., Melton, D. (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 5: 258-65.
Notice to Purchaser	Purchaser represents and warrants that it will use Stemolecule™ (-)-Indolactam V purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.

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MSDS

• Material Safety Data Sheet

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