Spec Sheet

Stemolecule™ SMO Antagonist

Catalog #	Size	Price (USD)	Quantity
04-0031	2 mg	$239.00	Qty:

Stemolecule™ SMO Antagonist is an analog of SANT-2, an inhibitor of Sonic hedgehog signaling. Hedgehog signaling is involved in embryogenesis as well as cancer progression. The mechanism of action of SMO Antagonist is allosteric inhibition of Smoothened (SMO), an integral membrane protein mediator of Hedgehog signaling.

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Stemolecule™ SMO Antagonist

References

Chen, J.K., Taipale, J., Young, K.E., Maiti, T., Beachy, P.A. (2002) Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99: 14071-6.
Gaffield, W., Incardona, J.P., Kapur, R.P., Roelink, H. (1999) A looking glass perspective: thalidomide and cyclopamine. Cell Mol Biol (Noisy-le-grand) 45: 579-88.
Jiang, J., Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-12.
Rominger, C.M., Bee, W.L., Copeland, R.A., Davenport, E.A., Gilmartin, A., Gontarek, R., Hornberger, K.R., Kallal, L.A., Lai, Z., Lawrie, K., Lu, Q., McMillan, L., Truong, M., Tummino, P.J., Turunen, B., Will, M., Zuercher, W.J., Rominger, D.H. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329: 995-1005.

Related Products
Stemolecule™ SHH Antagonist (Cat. No. 04-0032)

For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ SMO Antagonist

Size / Quantity	2 mg
Lot Number	1194
Alternate Name	N-(4-chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)-phenyl)-3,5-dimethoxybenzamide
Chemical Formula	C₂₄H₂₃ClN₄O₃
Molecular Weight	450.92
CAS Number	N/A
Structure
Formulation	Yellow powder
Purity	95.9%
Solubility	Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 444 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	Store at 4^oC. Protect from light. Following reconstitution, store aliquots at -20C.
Stability	Stock solutions stable at -20°C for 6 months.
Quality Control	The purity of SMO Antagonist was determined by HPLC analysis. The accurate mass and structure of SMO Antagonist was determined by mass spectrometry and NMR, respectively. Cellular toxicity of SMO Antagonist was tested on mouse ES cells.
References	Chen, J.K., Taipale, J., Young, K.E., Maiti, T., Beachy, P.A. (2002) Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99: 14071-6. Gaffield, W., Incardona, J.P., Kapur, R.P., Roelink, H. (1999) A looking glass perspective: thalidomide and cyclopamine. Cell Mol Biol (Noisy-le-grand) 45: 579-88. Jiang, J., Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-12. Rominger, C.M., Bee, W.L., Copeland, R.A., Davenport, E.A., Gilmartin, A., Gontarek, R., Hornberger, K.R., Kallal, L.A., Lai, Z., Lawrie, K., Lu, Q., McMillan, L., Truong, M., Tummino, P.J., Turunen, B., Will, M., Zuercher, W.J., Rominger, D.H. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329: 995-1005.
Related Products	Stemolecule™ SHH Antagonist (Cat. # 04-0032)
Notice to Purchaser	Purchaser represents and warrants that it will use Stemolecule™ SMO Antagonist purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.