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Product Overview
References
- Chen, J.K., Taipale, J., Young, K.E., Maiti, T., Beachy, P.A. (2002) Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A 99: 14071-6.
- Gaffield, W., Incardona, J.P., Kapur, R.P., Roelink, H. (1999) A looking glass perspective: thalidomide and cyclopamine. Cell Mol Biol (Noisy-le-grand) 45: 579-88.
- Jiang, J., Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-12.
- Rominger, C.M., Bee, W.L., Copeland, R.A., Davenport, E.A., Gilmartin, A., Gontarek, R., Hornberger, K.R., Kallal, L.A., Lai, Z., Lawrie, K., Lu, Q., McMillan, L., Truong, M., Tummino, P.J., Turunen, B., Will, M., Zuercher, W.J., Rominger, D.H. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther 329: 995-1005.
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Size / Quantity |
2 mg
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| Lot Number |
1194
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| Alternate Name |
N-(4-chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)-phenyl)-3,5-dimethoxybenzamide
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| Chemical Formula |
C24H23ClN4O3
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| Molecular Weight |
450.92
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| CAS Number |
N/A
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| Structure |
![[structure graphics]](/products/04-0031/images/structure.jpg)
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| Formulation |
Yellow powder
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| Purity |
95.9%
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 444 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
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| Stability |
Stock solutions stable at -20°C for 6 months.
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| Quality Control |
The purity of SMO Antagonist was determined by HPLC analysis. The accurate mass and structure of SMO Antagonist was determined by mass spectrometry and NMR, respectively. Cellular toxicity of SMO Antagonist was tested on mouse ES cells.
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| Related Products |
Stemolecule™ SHH Antagonist (Cat. # 04-0032)
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| Notice to Purchaser |
Purchaser represents and warrants that it will use Stemolecule™ SMO Antagonist
purely for research purposes, not for diagnostic use, not
for resale, and not for use in humans or veterinary applications.
Stemgent will not be held responsible for patent infringement or
other violations that may occur with the use of our products.
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Technical Documents
Specifications
MSDS
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