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Product Overview
Stemolecule™ SHH Antagonist is an inhibitor of Sonic hedgehog signaling (SHH)1. Hedgehog signaling plays key roles in a wide variety of development process2 as well as cancer progression3. The vertebrate family of hedgehog genes that have been identified are known as Sonic (Shh), Desert (Dhh), and Indian (Ihh) hedgehogs, all of which encode secreted proteins. Among the three, Sonic hedgehog (SHH) is the best studied ligand of the vertebrate pathway. One of the best studied examples is the action of Sonic hedgehog during development of the vertebrate limb, in which both the concentration and the time of exposure to SHH determines which digit into which the tissue will develop4. Stemolecule™ SHH Antagonist is the result of a compound screening for inhibiting activation of the hedgehog signaling pathway, e.g. inhibition of aberrant growth states resulting from phenotypes such as hedgehog gain-of-function1.
References
- The Genomics Institute of the Novartis Research Foundation. Compounds and compositions as Hedgehog pathway modulators. World Patent WO 2006050351 (2006).
- Ingham, P.W. and McMahon, A.P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev 15: 3059-3087
- Jiang, J., Hui, C.C. (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-12.
- Harfe, B.D., Scherz, P.J., Nissim, S., Tian, H., McMahon, A.P., and Tabin, C.J. (2004) Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118: 517-528
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Size / Quantity |
2 mg
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| Lot Number |
1195
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| Alternate Name |
N-(4-ethoxyphenyl)-4-(2-methylimidazol[1,2-a]pyridine-3-yl)thiazol-2-amine, 2-amino-thiazole, Sonic hedgehog antagonist
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| CAS Number |
N/A
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| Chemical Formula |
C19H18N4OS
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| Structure |
![[structure graphics]](/products/04-0032/images/structure.jpg)
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| Formulation |
light pink color
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| Molecular Weight |
350.44
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| Purity |
>99%
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 571 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20oC.
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| Stability |
Stock solutions stable at -20°C for 6 months.
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| Quality Control |
The purity of SHH Antagonist was determined by HPLC analysis. The accurate mass and structure of SHH Antagonist were determined by mass spectrometry and NMR, respectively. Cellular toxicity of SHH Antagonist was tested on mouse ES cells.
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| Related Products |
Stemolecule™ SMO Antagonist (Cat. # 04-0031)
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| Notice to Purchaser |
Purchaser represents and warrants that it will use Stemolecule™ SHH Antagonist
purely for research purposes, not for diagnostic use, not
for resale, and not for use in humans or veterinary applications.
Stemgent will not be held responsible for patent infringement or
other violations that may occur with the use of our products.
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Technical Documents
Specifications
MSDS
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