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Product Overview
Stemolecule™ Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway1. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It has an IC50 of 27 nM and blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.
References
- Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S., Roth, M.G., Amatruda, J.F., Chen, C., Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-7.
For research use only. Not for use in diagnostic procedures. Not for resale.
Product Specifications
| Size / Quantity |
2 mg
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| Lot Number |
1197
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| Alternate Name |
2-(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide
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| Chemical Formula |
C22H18N4O2S3
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| Structure |
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| Molecular Weight |
466.6
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| CAS Number |
686770-61-6
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| Purity |
>99%
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| Formulation |
White powder
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| Solubility |
Soluble in DMSO (100 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 429 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
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| Storage |
Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C.
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| Stability |
Stock solutions stable at -20°C for 6 months.
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| Quality control |
The purity of Wnt Inhibitor IWP-2 was determined by HPLC analysis. The accurate mass and structure of Wnt Inhibitor IWP-2 was determined by mass spectrometry and NMR, respectively. Cellular toxicity of Wnt Inhibitor IWP-2 was tested on mouse ES cells.
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| Related Products |
Stemolecule™ Wnt Inhibitor IWP-4 (Cat. # 04-0036)
Stemolecule™ Wnt Inhibitor IWP-3 (Cat. # 04-0035)
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| Notice to Purchaser |
Purchaser represents and warrants that it will use Stemolecule™ Wnt Inhibitor IWP-2
purely for research purposes, not for diagnostic use, not
for resale, and not for use in humans or veterinary applications.
Stemgent will not be held responsible for patent infringement or
other violations that may occur with the use of our products.
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Technical Documents
Specifications
MSDS
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