Stemolecule™ Cyclic Pifithrin-α

Stemolecule™ Cyclic Pifithrin-α

Stemolecule™ Cyclic Pifithrin-α (Cyclic PFT-α) is a transcriptional inhibitor of p53. Cyclic PFT-α was found to be one log more potent than the p53 inactivator Pifithrin-α with EC₅₀ values ranging around 30 nM. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. Cyclic PFT-α sensitizes tumor cells to antimicrotubule agent induced apoptosis.

References

1. Pietrancosta, N., Maina, F., Dono, R., Moumen, A., Garino, C., Laras, Y., Burlet, S., Quelever, G., Kraus J. (2005) Novel cyclized Pifithrin-α inactivators: synthesis and biological studies. Bioorg Med Chem Lett 15: 1561-1564.
2. Zuco, V., Zunino, F. (2005) Cyclic Pifithrin- α sensitizes wild type p53 tumor cells to antimicrotubule agent- induced apoptosis. Neoplasia 10: 587-596.

For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ Cyclic Pifithrin-α

Size / Quantity	5 mg
Alternate Name	Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide
Chemical Formula	C16H18N2S-HBr
Structure
Formulation	White to off-white solid
Molecular Weight	349.29
Purity	≥95%
Solubility	Soluble in DMSO (57 mM). For a 10 mM concentrated stock solution, reconstitute the compound by adding 1458 µl of DMSO to the entire contents of the vial. Note: for most cells, the maximum tolerance to DMSO is <0.5%.
Storage	Store at 4oC. Protect from light. Following reconstitution, store aliquots at -20C.
Quality Control	The purity of Cyclic Pifithrin-α was determined by HPLC analysis. The accurate mass of Cyclic Pifithrin-α was determined by mass spectrometry. Cellular toxicity of Cyclic Pifithrin-α was tested on mouse embryonic stem cells.
References	Pietrancosta, N., Maina, F., Dono, R., Moumen, A., Garino, C., Laras, Y., Burlet, S., Quelever, G., Kraus J. (2005) Novel cyclized Pifithrin-α inactivators: synthesis and biological studies. Bioorg Med Chem Lett 15: 1561-1564. Zuco, V., Zunino, F. (2005) Cyclic Pifithrin- α sensitizes wild type p53 tumor cells to antimicrotubule agent- induced apoptosis. Neoplasia 10: 587-596.
Notice to Purchaser	Purchaser represents and warrants that it will use Stemolecule™ Cyclic Pifithrin-α purely for research purposes, not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.
Stability	Stock solutions stable at -20°C for 6 months.

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