Spec Sheet

Stemolecule™ MAPK Signaling Pathway Modulator Set

Catalog #	Size	Price (USD)	Quantity
00-0041	3 compounds	$359.00	Qty:

The Stemolecule™ MAPK Signaling Pathway Modulator Set consists of three cell-permeable small molecules: PD0325901, PD173074, and SC1 (Pluripotin), which can modulate the MAPK signaling cascade. PD0325901 is a MEK inhibitor; PD173074 is an ATP-competitive inhibitor of the FGF receptor, known to activate the MAPK/ERK cascade; and SC1 (Pluripotin) acts through dual inhibition of ERK 1 and Ras-GAP. Each small molecule is tested for purity, accurate mass and structure, and toxicity in mouse embryonic stem cells.

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Stemolecules™ PD0325901, PD173074, and SC1(Pluripotin) modulate MAPK signaling.

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Stemolecule™ MAPK Signaling Pathway Modulator Set

The Stemolecule™ MAPK Signaling Pathway Modulator Set contains three cell permeable small molecules known to modulate the mitogen-activated protein kinase (MAPK) signaling cascade. Stemolecule™ PD0325901 inhibits mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK). Stemolecule™ PD173074 is an ATP-competitive inhibitor of the fibroblast growth factor (FGF) receptor, which is known to activate the MAPK/ERK cascade. Stemolecule™ SC1 (Pluripotin) acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP).

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For research use only. Not for use in diagnostic procedures. Not for resale.

Stemolecule™ MAPK Signaling Pathway Modulator Set

Size	3 compounds
Lot Number	1260
Quantity / Size	3 compounds
Set Components	1. Stemolecule™ PD0325901 (Cat. No. 04-0006), 2 mg, Lot# 1144 2. Stemolecule™ PD173074 (Cat. No. 04-0008), 2 mg, Lot# 1161 3. Stemolecule™ SC1 (Pluripotin) (Cat. No. 04-0011), 1 mg, Lot# 1051
Storage	Store at 4°C. Protect from light. Following reconstitution, store aliquots at -20°C.
Stability	Components are stable for 6 months from date of receipt when stored as directed.
Quality control	The purity of Stemgent’s Stemolecules™ was determined by HPLC analysis. The accurate mass and structure of Stemgent’s Stemolecules™ were determined by mass spectrometry and NMR, respectively. Cellular toxicity of Stemgent’s Stemolecules™ was tested on mouse embryonic stem cells.
Recommended Usage	Refer to individual Stemolecule™ specification sheets.
Related Products	Stemolecule™ TGF-β Signaling Pathway Modulator Set (Cat.No.00-0038) Stemolecule™ Epigenetic Modifier Set (Cat.No.00-0039) Stemolecule™ iPS Cell Enhancer Set (Cat.No.00-0040)
Notice to Purchaser	Purchaser represents and warrants that it will use the Stemolecule™ MAPK Signaling Pathway Modulator Set purely for research purposes. Not for diagnostic use, not for resale, and not for use in humans or veterinary applications. Stemgent will not be held responsible for patent infringement or other violations that may occur with the use of our products.