Small molecules have proven to be invaluable as effectors of stem cells. To promote self-renewal and achieve precise control of stem cell differentiation, access to a vast library of small molecule modulators is an important research tool. Here are just a few reasons why.
- Easy cell penetration.
- Very low antigenicity.
- Work across multiple cell signalling pathways.
- Easily affect epigenetic modifications.
Stemgent has precisely the small molecules you need for stem cell research, including some you won't find anywhere else, such as CHIR99021 and PD0325901. You can count on the purity of all the small molecule products in the Stemolecule line. You can also expect a growing number of small molecule products with special relevance to almost all stem cell researchers.
| Cat. no. | Name | Product description | Qty. | Price (USD) | |
|---|---|---|---|---|---|
| 04-0013 | Stemolecule™ R(+)Bay K 8644 | Enhances MEF reprogramming efficiency with only Oct3/4 and Klf4, by activating L-type Ca2+ channel, when used in combination with BIX01294. Shi, Y. et al., Cell Stem Cell 3(5): 568-574 (2008) | 5 mg | 149.00 | |
| 04-0014 | Stemolecule™ A83-01 | Inhibits the TGF-β-induced epithelial-to-mesenchymal transition by blocking Smad2 phosphorylation by ALK-4, -5, and -7. Tojo, M. et al., Cancer Sci 96: 791-800 (2005) | 2 mg | 119.00 | |
| 04-0015 | Stemolecule™ ALK5 Inhibitor | Increases the efficiency of reprogramming of rat liver progenitor cells and IMR90 human fibroblast cells by inhibiting TGF-β receptor ALK-5. Li, W. et al., Cell Stem Cell 4: 16-19 (2009) | 1 mg | 99.00 | |
| 04-0033 | Stemolecule™ Tranylcypromine Hydrochloride | Derepresses Oct4 expression in P19 embryonal carcinoma cells by inhibiting monoamine oxidase. Lee, M.G. et al., Chem Biol 13: 563-567 (2006) | 10 mg | 49.00 | |
| 04-0001 | Stemolecule™ RG108 | Inhibits DNA methyl transferase with no cytotoxic effect . Highest purity available only from Stemgent. Brueckner, B., et al, Cancer Res. 65, 6305-6311 (2005) | 10 mg | 129.00 | |
| 04-0002 | Stemolecule™ BIX01294 | Reprograms neural progenitor cells in the presence of only two transcription factors, Oct3/4 and Klf-4 Shi, Y. et al., Cell Stem Cell, 2:525-528 (2008) | 5 mg | 99.00 | |
| 04-0005 | Stemolecule™ Sodium Butyrate | Differentiates human ESCs into defininitive endoderm cells by Inhibiting Histon deacetylatse 2. Lallemand, F. et al., Biochem. Biophys. Res. Commun., 229(1):163-169 (1996), and Kruh, J., Mol. Cell. Biochem. ,42(2):65-82 (1982) | 500 mg | 49.00 | |
| 04-0007 | Stemolecule™ Valproic Acid | Enhances iPS generation without introduction of the c-Myc oncogene1. Huangfu, D. et al., Nat. Biotechnol., 2008, (published online June 22, 2008) | 5 g | 49.00 | |
| 04-0030 | Stemolecule™ Rock II Inhibitor | Stemolecule™ Rock II Inhibitor is a specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase (Rock). Rock inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 | |
| 04-0029 | Stemolecule™ Rock I Inhibitor | Rock inhibitors, including Stemolecule™ Rock I Inhibitor, have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 | |
| 04-0040 | Stemolecule™ Cyclic Pifithrin-α | Stemolecule™ Cyclic Pifithrin-a (Cyclic PFT-a) is a transcriptional inhibitor of p53. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. Cyclic PFT-a sensitizes tumor cells to antimicrotubule agent induced apoptosis. | 5 mg | 109.00 | |
| 04-0038 | Stemolecule™ Pifithrin-α | Stemolecule™ Pifithrin-a (PFT-a) is a small molecule inhibitor of p53 dependent apoptosis and transcriptional activation for cyclin G, p21/waf1, and mdm2 expression. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. | 5 mg | 99.00 |
| Cat. no. | Name | Product description | Qty. | Price (USD) | |
|---|---|---|---|---|---|
| 04-0003 | Stemolecule™ BIO | Maintains self-renewal in human and mouse embryonic stem cells by inhibiting GSK3. Sato, N. et al., Nat Med 10:1, 55-63 (2004) | 2 mg | 99.00 | |
| 04-0004 | Stemolecule™ CHIR99021 | Enables self-renewal of ESCs by blocking GSK3β to activate Wnt signaling pathway. Ying Q.-L. et al., Nature 53:519-523 (2008) | 2 mg | 239.00 | |
| 04-0006 | Stemolecule™ PD0325901 | Sustains efficient ESC renewal in combination with CHIR99021 only, by suppressing ERK activation.Ying Q.-L. et al., Nature 53:519-523 (2008) | 2 mg | 239.00 | |
| 04-0008 | Stemolecule™ PD173074 | Supports self-renewal of mESCs when combined with CHIR99021 and PD0325901, by inhibiting the FGF signaling pathway. Mohammadi, M. et al., EMBO J. 17:5896-5904 (1998) | 2 mg | 119.00 | |
| 04-0011 | Stemolecule™ SC1 (Pluripotin) | Enables self-renewal of mouse ESCs by dual inhibition of ERK1 and Ras -GAP. Chen, S. et al., Proc Natl Acad Sci USA 103(46): 17266-17271 (2006) | 1 mg | 99.00 | |
| 04-0012 | Stemolecule™ Y27632 | Enhances survival and cloning efficiency of ESCs by inhibiting ROCK. Watanabe, K. et al., Nat Biotechnol 25: 681-686 (2007) | 2 mg | 139.00 | |
| 04-0030 | Stemolecule™ Rock II Inhibitor | StemoleculeTM Rock II Inhibitor is a specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase (Rock). Rock inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 | |
| 04-0029 | Stemolecule™ Rock I Inhibitor | Rock inhibitors, including Stemolecule™ Rock I Inhibitor, have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 |
| Cat. no. | Name | Product description | Qty. | Price (USD) | |
|---|---|---|---|---|---|
| 04-0009 | Stemolecule™ Purmorphamine | Promotes differentiation of human and murine mesenchymal progenitor cells into osteoblasts by activating Hedgehog signaling pathway. Wu, X. et al., J Am Chem Soc. 124:14520-14521 (2002), and Beloti, M. M. et al., Journal of Cell Biology International 29 (7):537-541 (2005) | 5 mg | 99.00 | |
| 04-0010 | Stemolecule™ SB431542 | Stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells by inhibiting TGFβ receptor signaling pathway. Inman, G. J. et al., Mol. Pharmacol., 62:65-74 (2002), and Watabe T. et al., J. Cell Biol., 163(6):1303-1311 (2003) | 5 mg | 99.00 | |
| 04-0021 | Stemolecule™ All-Trans Retinoic Acid | Differentiates stem cells to β-cells, T-cells and neurons. Ertesvag, A. et al., Semin Immunol 21: 36-41 (2009), Yagi, J. et al., Cell Immunol 181: 153-162 (1997), Dhara, S.K. et al., J Cell Biochem 105: 633-640 (2008), Takahashi, J. et al., J Neurobiol 38: 65-81 (1999), and Wichterle, H. et al., Cell 110: 385-397 (2002) | 100 mg | 89.00 | |
| 04-0022 | Stemolecule™ Cyclopamine | Modulates cell proliferation and differentiation to definitive endoderm pancreatic islet cells by inhibiting SHH signaling. Gallo, R. et al., Ann N Y Acad Sci 1150: 43-45 (2008) and D'Amour, K.A. et al., Nat Biotechnol 24: 1392-1401 (2006) | 2 mg | 159.00 | |
| 04-0023 | Stemolecule™ Dexamethasone | Modulates osteogenesis or adipogenesis of MSCs by binding to glucocorticoid receptors. Grigoriadis, A.E. et al., J Cell Biol 106: 2139-2151 (1988) and Jaiswal, N. et al., J Cell Biochem 64: 295-312 (1997) | 200 mg | 49.00 | |
| 04-0024 | Stemolecule™ Dorsomorphin | Inhibits iron-hepcidin homeostasis and promotes cardiomyogenesis by antagonizing BMP signaling. Yu, P.B. et al., Nat Chem Biol 4: 33-41 (2008), Hao, J. et al., PLoS ONE 3: e2904 (2008), and Seib, F.P. et al., Eur J Cell Biol 88: 257-271 (2009) | 2 mg | 109.00 | |
| 04-0025 | Stemolecule™ Forskolin | Potentiates neuron differentiation by stimulating adenylate cyclase. Son, H. et al., Neurosci Lett 308: 37-40 (2001) and Palmer, T.D. et al., Mol Cell Neurosci 8: 389-404 (1997) | 10 mg | 149.00 | |
| 04-0028 | Stemolecule™ KAAD-Cyclopamine | Halts migration or proliferation of a variety of cancer cells (e.g. esophageal, gastrointestinal, hepatic and pancreatic cancer) by inhibiting SHH signaling. Ma, X. et al., Carcinogenesis 26: 1698-1705 (2005), Ma, X. et al., Int J Cancer 118, 139-148 (2006), Sicklick, J.K. et al., Carcinogenesis 27: 748-757 (2006), and Cheng, W.T. et al., Int J Oncol 34: 829-836 (2009) | 100 µg | 249.00 | |
| 04-0030 | Stemolecule™ Rock II Inhibitor | StemoleculeTM Rock II Inhibitor is a specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase (Rock). Rock inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 | |
| 04-0029 | Stemolecule™ Rock I Inhibitor | Rock inhibitors, including Stemolecule™ Rock I Inhibitor, have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency. | 2 mg | 239.00 | |
| 04-0019 | Stemolecule™ BMP Inhibitor LDN-193189 | Stemolecule™ BMP Inhibitor LDN-193189 functions primarily through inhibition of BMP type I receptors ALK2 and ALK3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. | 2 mg | 239.00 | |
| 04-0020 | Stemolecule™ (-)-Indolactam V | Stemolecule™ (-)-Indolactam V is a PKC isozyme inhibitor identified in a high-content chemical screen as a small molecule inducer of human embryonic stem cell differentiation to functional insulin-secreting beta cells at the definitive endoderm cell stage. | 300 μg | 109.00 | |
| 04-0032 | Stemolecule™ SHH Antagonist | Stemolecule™ SHH Antagonist is an inhibitor of Sonic hedgehog signaling (SHH). Hedgehog signaling is involved in embryogenesis as well as cancer progression. The mechanism for this antagonist is unknown. | 2 mg | 239.00 | |
| 04-0031 | Stemolecule™ SMO Antagonist | Stemolecule™ SMO Antagonist is an analog of SANT-2, an inhibitor of Sonic hedgehog signaling. Hedgehog signaling is involved in embryogenesis as well as cancer progression. The mechanism of action of SMO Antagonist is allosteric inhibition of Smoothened (SMO), an integral membrane protein mediator of Hedgehog signaling. | 2 mg | 239.00 | |
| 04-0036 | Stemolecule™ Wnt Inhibitor IWP-4 | Stemolecule™ Wnt Inhibitor IWP-4 is an antagonist of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It blocks phosporylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. | 2 mg | 99.00 | |
| 04-0035 | Stemolecule™ Wnt Inhibitor IWP-3 | Stemolecule™ Wnt Inhibitor IWP-3 is an antagonist of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. | 2 mg | 99.00 | |
| 04-0034 | Stemolecule™ Wnt Inhibitor IWP-2 | Stemolecule™ Wnt Inhibitor IWP-2 is an antagonist of the Wnt/β-catenin pathway1. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. | 2 mg | 99.00 | |
| 04-0027 | Stemolecule™ IDE-2 | Stemolecule™ IDE-2 is an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells in mouse and human ES cell cultures. IDE-2 chemically induced endoderm can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos. | 2 mg | 239.00 | |
| 04-0026 | Stemolecule™ IDE-1 | Stemolecule™ IDE-1 is an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells in mouse and human ES cell cultures. Endoderm chemically induced by IDE-1 can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos. | 2 mg | 239.00 |
Interested in exploring the possibilities? Call Stemgent right away and speak with any scientist in our Small Molecules Group. We're at speed on all the research and our world-renowned Scientific Advisory Board keeps us on the cutting edge. We're ready to help you plan your experiments and choose the right small molecules.