Publications
In vivo reprogramming of adult pancreatic exocrine cells to b-cells
Researchers have transformed ordinary cells into insulin-producing cells in a living mouse, improving symptoms of diabetes in a major step towards regenerative medicine.
Enrichment and Differentiation of Human Germ-like Cells Mediated by Feeder Cells and Basic Fibroblast Growth Factor Signaling
August 22, 2008
Scientists find that bFGF can significantly enrich germ cell differentiation from hESCs.
Spermatogonial Stem Cell Self Renewal Requires OCT4, A Factor Down-Regulated During Retinoic Acid Induced Differentiation
August 22, 2008
Researchers find retinoic acid to trigger spermatogonial differentiation through the direct or indirect down-regulation of OCT4 and PLZF.
Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts
August 21, 2008
Scientists use an additional gene or bioactive molecule to increase the efficiency of generating iPS cells from human adult as well as fetal fibroblasts.
Feeder-free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile
August 20, 2008
Scientists suggest that on tissue culture substrates, vimentin expression is most likely a stress-induced response, unrelated to differentiation.
Emergence of Patterned Stem Cell Differentiation within Multicellular Structures
August 19, 2008
Scientists suggest a role for mechanical forces in linking multicellular organization to spatial differentials of cell differentiation, and represent an important guiding principle in tissue patterning that could be exploited in stem cell-based therapies.
Paraxial Mesodermal Progenitors Derived from Mouse Embryonic Stem Cells Contribute to Muscle Regeneration via Differentiation into Muscle Satellite Cells
August 13, 2008
Scientists show the potential of ES cell-derived paraxial mesodermal progenitor cells to generate functional muscle stem cells in vivo without inducing or supressing gene manipulation.
BM88/Cend1 Expression Levels Are Critical for Proliferation and Differentiation of Subventricular Zone-Derived Neural Precursor Cells
August 13, 2008
BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal subventricular zone (SVZ) neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels.
Disease-Specific Induced Pluripotent Stem Cells
August 13, 2008
Disease- Specific stem cells offer an opportunity for scientists to recapulate both normal and patologic human tissue formation in vitro, enabling disease investigation and drug development.
Zfp143 regulates Nanog through modulation of Oct4 binding
August 11, 2008
Scientists have found that zinc finger protein, Zfp143 regulates Nanog expression through modulation of Oct4 binding.
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