RNA Reprogramming Systems for Fibroblasts and Blood
Highly Efficient Reprogramming
ReproCELL's Stemgent® RNA reprogramming technology provides the highest efficiencies (greater than 1%) of any widely used reprogramming technology. In addition to increased yield of colonies and fast reprogramming kinetics, RNA-based reprogramming does not require laborious multi-step downstream passaging or screening for viral vector retention or genomic integration, and gives the lowest rates of genetic abnormalities.
Multi-target Reprogramming (Fibroblasts, Blood, Urine)
The Stemgent StemRNA-NM reprogramming system, combining StemRNA™-NM Reprogramming Kit (00-0076) with Nippi iMatrix-511 Stem Cell Culture Substrate (NP892-011), provides high-quality reprogramming of adult and neonatal fibroblasts, endothelial progenitors cells from peripheral or cord blood, and urine-derived cells. This kit provides high efficieincies (up to 4% with fibroblasts) with flexibilty in target cells, in one easy-to-use kti.
The Stemgent StemRNA™-SR Reprogramming Kit (00-0075), using self-replicative RNA, is the first RNA-based reprogramming kit for blood derived cells. Starting with genetically stable endothelial progenitor cells (EPCs), easily isolated from whole blood or frozen MNCs, this technology can efficiently generate, with only two transfections, iPSCs which are free of reprogramming vector and ready to differentiate or scale up.