Stemolecule™ Sodium Butyrate

Catalog Size Price Quantity
04-0005 500 mg $51.00
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04 0005 Figure 1

Product Overview

Sodium Butyrate is the sodium salt of the short-chain fatty acid butyric acid. It is a metabolite of intestinal bacteria, a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract1. Sodium butyrate is also a known inhibitor of histone deacetylases (HDACs)2. HDAC inhibitors are promising anti-tumour agents that work by inhibiting cell proliferation and survival3. Along with the cytokines Activin A and acidic fibroblast growth factor (aFGF), sodium butyrate has been shown to direct the differentiation of mouse embryonic stem (ES) cells into hepatycytes4. Sodium Butyrate has also been reported to increase the efficiency of transfection and expression for both transient and stable transfections5.


Product Specifications

Size

500 mg

Alternate Name

Butyric acid sodium salt

Chemical Formula

C4H7NaO2

Molecular Weight

111.1

CAS Number

156-54-7

Purity

Greater than 98% by acid base titration

Formulation

White solid

Solubility

For a 100 mM concentrated stock solution of Sodium Butyrate, add 9 ml of water to 100 mg of the compound. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For cell culture, the medium should be prewarmed prior to supplementing with the reconstituted compound. This molecule is soluble in water at 900 mM.

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed.

Quality Control

The purity of Sodium Butyrate was determined by acid base titration. The accurate mass was determined by mass spectrometry. Cellular toxicity of Sodium Butyrate was tested on HeLa and HEK293 cells.

Related Products

  • Stemfactor™ Activin A (Human Recombinant) (Cat.No.03-0001)

Specification Sheets

Safety Data Sheets

References

  1. Säemann, M.D., Böhmig, G.A., Osterreicher, C.H., Burtscher, H., Parolini, O., Diakos, C., Stöckl, J., Hörl, W.H., Zlabinger, G.J. (2000) Anti-inflamatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J. 14: 2380-2382.
  2. Kruh, J. (1982) Effecs of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 42: 65-82.
  3. Mühlethaler-Mottet, A., Meier, R., Flahaut, M., KBourloud, K.B., Nardou, K., Joseph, J.M., and Gross, N. (2008) Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells. Mol Cancer 7: 55.
  4. Zhou, M., Li, P., Tan, L., Qu, S., Ying, Q.L., Song, H. (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J Cell Biochem 109: 606-614.
  5. Goding, C.R., and Russell, W.C. (1983) S1 sensitive sites in adenovirus DNA. Nucleic Acids Res. 11: 21-36.

Additional Publications



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