Stemolecule™ PD173074

Catalog Size Price Quantity
04-0008 2 mg $119.00
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PD173074 Figure 1

Product Overview

Stemolecule PD173074 is a potent, cell-permeable ATP-competitive inhibitor of fibroblast growth factor (FGF) receptor1. Inhibition of the FGF signaling pathway by PD173074 leads to self-renewal of stem cells in many systems, including mouse and human2,3. PD173074 has also been found to suppress tumor growth in a wide variety of cancers through it’s interaction with FGF receptors4,5


Product Specifications

Size

2 mg

Alternate Name

1-t-Butyl-3-(6-(3,5- dimethoxyphenyl)-2- (4-diethylaminobutylamino)- pyrido[2,3-d]pyrimidin- 7-yl)urea

Chemical Formula

C28H41N7O3 

Molecular Weight

523.7 

CAS Number

219580-11-7

Purity

Greater than 98% by HPLC analysis

Formulation

Yellow solid

Solubility

For a 10 mM concentrated stock solution of PD173074, reconstitute the compound by adding 381.9 μl of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM. 

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. 

Quality Control

The purity of PD173074was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of PD173074was tested on HeLa and HEK293 cells. 


Specification Sheets

Safety Data Sheets

References

  1. Mohammadi, M., Froum, S., Hamby, J.M., Schroeder, M.C., Panek, R.L., Lu, G.H., Eliseenkova, A.V., Green, D., Schlessinger, J., and Hubbard, S.R. (1998) Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 17: 5896-5904.
  2. Zaragosi, L.E., Ailhaud, G., Dani, C. (2006) Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 24: 2412-2419.
  3. Ying, Q.L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., and Smith, A. (2008) The ground state of embryonic stem cell self renewal. Nature 453: 519-523.
  4. Dimitroff, C.J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., Steinkempf, R., Schroeder, M., Klutchko, S., Sumlin, A., Henderson, B., Dougherty, T.J, and Bernacki, R.J. (1999) Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs 17: 121-135.
  5. St Bernard, R., Zheng, L., Liu, W., Winer, D., Asa, S.L., and Ezzat, S. (2005) Fibroblast growth factor receptors as molecular targets in thyroid carcinoma. Endocrinology 147: 1145-1153.

Additional Publications



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