Stemolecule™ IPA-3

This product has been discontinued.

04 0037 Figure 1

Product Overview

Stemolecule IPA-3 is an allosteric inhibitor of p21-activated kinase (Pak) activation. IPA-3 also inhibits the activation of related Pak kinase isoforms, but not more distantly related Pak kinases or other kinases. IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc421. Increasing data implicates Pak1 in tumorigenesis and metastasis, thus suggesting that IPA-3 could be a novel oncologic therapy2. Since Pak1 is also implicated as a critical downstream effector of protein kinase C, IPA-3 may prevent differentiation in some tissue development.  

Product Specifications


5 mg

Alternate Name


Chemical Formula


Molecular Weight


CAS Number



Greater than 97% by HPLC analysis 


Off white to yellow powder


For a 10 mM concentrated stock solution of IPA-3, reconstitute the compound by adding 1.43 mL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 °C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.

Storage and Stability

Store powder at 4 °C protected from light. Following reconstitution, store aliquots at -20 °C. Stock solutions are stable for 6 months when stored as directed.

Quality Control

The purity of IPA-3 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of IPA-3 was tested on mouse embryonic stem cells. 

Specification Sheets

Safety Data Sheets

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