Stemolecule™ XAV939

Catalog Size Price Quantity
04-0046 2 mg $199.00
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04 0046 Figure 1

Product Overview

Stemolecule XAV939 is a cell-permeable small molecule inhibitor of the Wnt / β-catenin pathway. XAV939 inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation1. Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state2. Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line1.           


Product Specifications

Size

2 mg

Alternate Name

2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol

Chemical Formula

C14H11F3N2OS

Molecular Weight

312.31

CAS Number

284028-89-3

Purity

Greater than 95% by HPLC analysis 

Formulation

White powder

Solubility

XAV939 is soluble in DMSO at 100 mM.

Reconstitution

For a 10 mM concentrated stock solution of XAV939, reconstitute the compound by adding 640.4 μl of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For use in cell culture, warm the medium just prior to adding the reconstituted compound. Once the compound is added, mix and filter-sterilize the medium using a 0.2 µM low-protein binding filter. 

Storage and Stability

Store powder at -20°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. 

Quality Control

The purity of XAV939 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM - 100 µM of XAV939. 


Specification Sheets

Safety Data Sheets



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