Stemolecule™ A769662

Catalog Size Price Quantity
04-0052 10 mg $179.00
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Product Overview

Stemolecule A769662 is a cell-permeable small molecule that activates AMP-activated protein kinase (AMPK). A769662, a thienopyridone, was identified as an effective AMPK activator by screening a chemical library of over 700,000 compounds1. The activation of AMPK inhibits mTOR (mammalian target of rapamycin) signaling, which is a positive affecter of cell growth, proliferation and survival2. A769662, therefore,may be useful as an inhibitor for both cell survival and cell proliferation.          


Product Specifications

Size

10 mg

Alternate Name

6-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-4-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile 

Chemical Formula

C20H12N2O3S

Molecular Weight

360.39

 CAS Number

844499-71-4

Purity

Greater than 98% by HPLC analysis 

 Formulation

White powder

Solubility

For a 10 mM concentrated stock solution of A769662, reconstitute the compound by adding 2.76 ml of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. 

Quality Control

The purity of A769662 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of A769662 was tested on mouse embryonic stem cells. 


Specification Sheets

Safety Data Sheets



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