Stemolecule™ LY411575

Catalog Size Price Quantity
04-0054 5 mg $200.00
Add To Cart
Order Offline
T: 877.228.9783
F: 617.812.5900
E: orders@stemgent.com

Bulk Orders? Call 877-303-2654 or fill out this form

Ly411575

Product Overview

Stemolecule LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor which blocks Notch activation1. Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. Concurrently, LY411575 inhibits cell proliferation2. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells3


Product Specifications

Size

5 mg

Alternate Name

N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide

Chemical Formula

C26H23F2N3O4

Molecular Weight

479.48

CAS Number

209984-57-6

Purity

Greater than 96% by HPLC analysis

Formulation

White powder

Solubility

For a 10 mM concentrated stock solution of LY411575, reconstitute the compound by adding 1.04 ml of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed.

Quality Control

The purity of LY411575 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of LY411575 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets



Stemgent Comments and Reviews (2)

Add a Comment

You must log-in or register as a Stemgent member to submit a comment.


Michael Andreas Just read an article about this. http://thepositive.com/science-cure-hearing-loss/ If true, this is fantastic news. It gives hope to millions that someday there may actually be a cure for this life altering ailment. Thanks and keep up the great work.
Oct 5, 2013
Matthew Mehana Hello. I recently just found out about compound "LY-411575". I've had slight hearing loss for the past 2 years and if feels like my ears are "clogged" due to all the frequency loss. Is this new compound a cure for hearing loss? And can it be taken my humans yet? Please reply, I haven't been myself since it suddenly happened. I hope this is at least a good start?
Jul 19, 2013

You are fully responsible for the content you post. We encourage collaboration and helpful reviews among scientists and will use this feature to conduct helpful reviews of our products. Content that includes profanity, personal attacks or antisocial behavior (such as "spamming" or "trolling"), or other inappropriate content or material will be removed. We reserve the right to block any user who violates our terms of use, including removing all content posted by that user.