Stemolecule™ LDN-193189

Catalog Size Price Quantity
04-0074 2 mg $203.00
04-0074-10 10 mg $799.00
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04 0074 Figure 1

Product Overview

LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK71. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189  has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1. Stemolecule LDN-193189 is a hydrochloride salt.

Also available: Stemolecule™ LDN-193189 in Solution (04-0074-02)
Discontinued Product Cat. No. 04-0019:  Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluable in chloroform, this salt-based form is soluable in DMSO for your convenience.

Product Specifications


2 mg (Cat. No. 04-0074)
10 mg (Cat. No. 04-0074-10)

Alternate Name

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride

Chemical Formula

C25H22N6 · HCl

Molecular Weight


CAS Number



Greater than 96% by HPLC analysis 


Yellow Powder


Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability

Store powder at 4°C protected from light.

Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solutions be freshly made and stored in aliquots at -20 °C. The effect of storage of stock solutions should be verified for each application.

Quality Control

The purity of LDN-193189 is determined by HPLC analysis. The molecular is determined by mass spectrometry ([M+1]+ = 407±0.5). No acute cytotoxicity (>75% viability) is observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM – 1 µM of LDN-193189.


  1. Yu, P.B., Deng, D.Y., Lai, C.S., Hong, C.C., Cuny, G.D., Bouxsein, M.L., Hong, D.W., McManus, P.M., Katagiri, T., Sachidanandan, C., Kamiya, N., Fukuda, T., Mishina, Y., Peterson, R.T., and Bloch, K.D. (2008) BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med 14: 1363-1369.
  2. Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Lin, H.Y., Bloch, K.D., and Peterson, R.T. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
  3. Cuny, G.D., Yu, P.B., Laha, J.K., Xing, X., Liu, J.F., Lai, C.S., Deng, D.Y., Sachidanandan, C., Bloch, K.D., and Peterson, R.T. (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett 18: 4388-4392.
  4. Heisenberg, C.P., and Solnica-Krezel, L. (2008) Back and forth between cell fate specification and movement during vertebrate gastrulation. Curr Opin Genet Dev 18: 311-316.
  5. Cain, J.E., Hartwig, S., Bertram, J.F., and Rosenblum, N.D. (2008) Bone morphogenetic protein signaling in the developing kidney: present and future. Differentiation 76: 831-842.

Additional Publications

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