Stemolecule™ PD0325901 in Solution

Catalog Size Price Quantity
04-0006-02 2 mg (10 mM) $239.00
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Product Overview

PD0325901 is a small molecule targeting mitogen-activated protein kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation1,2. Along with the ALK5 inhibitor SB431542, PD0325901 has also been shown to increase the efficiency of reprogramming human primary fibroblasts into induced pluripotent stem (iPS) cells3.

Stemolecule PD0325901 in Solution is a ready to use 10 mM stock solution for stem cell culture.


Product Specifications

Size

2 mg

Concentration

10 mM in DMSO

Alternate Name

N-​[(2R)-​2,​3-​dihydroxypropoxy]-​3,​4-​difluoro-​2-​[(2-​fluoro-​4-​iodophenyl)amino]-​benzamide

Chemical Formula

C16H14F3IN2O

Molecular Weight

482.19

CAS Number

391210-10-9

Purity

Greater than 97% by HPLC analysis

Formulation

10 mM solution of PD0325901 in DMSO (2 mg in 414.8 μl)

Handling

Before opening, briefly centrifuge the vial to ensure full recovery of sample. Aliquotting the stock solution is recommended to avoid repetitive freeze-thaw cycles. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%.

Storage and Stability

Store solution at -20°C protected from light. Stable for 6 months from date of receipt when stored as directed.

Quality Control

The purity of PD0325901 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of PD0325901 was tested on mouse embryonic stem cells.


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