Stemolecule™ LDN-193189 in Solution

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04-0074-02 2 mg (10 mM) $239.00
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04 0074 Figure 1

Product Overview

LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK71. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189  has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1.

Stemolecule LDN-193189 in Solution is a ready to use 10 mM stock solution for stem cell culture.

Product Specifications


2 mg


10 mM in DMSO

Alternate Name

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride

Chemical Formula

C25H22N6 · HCl

Molecular Weight


CAS Number



Greater than 96% by HPLC analysis


10 mM solution of LDN-193189 in DMSO (2 mg in 451.5 μl)


Before opening, briefly centrifuge the vial to ensure full recovery of sample. Aliquotting the stock solution is recommended to avoid repetitive freeze-thaw cycles. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%.

Storage and Stability

Store solution at -20°C protected from light. Stable for 6 months from date of receipt when stored as directed.

Quality Control

The purity of LDN-193189 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of LDN-193189 was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets

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