Stemolecule™ IM-12

Catalog Size Price Quantity
04-0081 2 mg $84.00
Add To Cart
Order Offline
T: 877.228.9783
F: 617.812.5900
Im 12 Structure

Product Overview

The indolylmaleimide IM-12 is a potent enzymatic (IC50= 52 nM, compared with 92 nM for SB-216763) and intracellular inhibitor of GSK-3β which activates downstream components of canonical Wnt signaling and increasing β-catenin levels. IM-12 promotes increased differentiation of neural progenitor cells to neurons1. IM-12 has been shown to support the conversion and maintenance of human naïve stem cells2.

Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

L: Stemfactor™ LIF, Human Recombinant (03-0016), and

A: Stemfactor™ Activin A, Human Recombinant (03-0001)

Product Specifications

Product Name

StemoleculeTM IM-12

Calalog Number



2 mg

Alternate Name


Chemical Formula


Molecular Weight


CAS Number



99% Purity by HPLC analysis


Orange solid


IM-12 is soluble in DMSO at 100 mM and in ethanol at 10 mM at room temperature.  For a 10 mM concentrated stock solution of IM-12, reconstitute the compound by adding 530 μL of DMSO to the entire contents of the vial.  If precipitate is observed, warm the solution to 37 C for 2 to 5 minutes. The maximum concentration recommended for dilution in media to ensure complete solubility is 10 μM For cell culture, the media should be pre-warmed prior to adding the reconstituted compountd. Note: for most cells, the maximum tolerance to DMSO is less than 0.5% by volume.

Storage and Stability

Store powder for up to six months at 4 C, protected from light. Following reconstitution, store aliquots at -20C.

Quality Control

The purity of IM-12 was determined by HPLC analysis.  The accurate mass was determined by mass spectrometry. Cellular toxicity of IM-12 was tested on mouse embryonic stem cells.

Specification Sheets

Safety Data Sheets

Stemgent Comments and Reviews (0)

No comments or reviews yet. Be the first to leave a review.

Add a Comment

You must log-in or register as a Stemgent member to submit a comment.

You are fully responsible for the content you post. We encourage collaboration and helpful reviews among scientists and will use this feature to conduct helpful reviews of our products. Content that includes profanity, personal attacks or antisocial behavior (such as "spamming" or "trolling"), or other inappropriate content or material will be removed. We reserve the right to block any user who violates our terms of use, including removing all content posted by that user.