Stemolecule™ WH-4-023

Catalog Size Price Quantity
04-0079 2 mg $179.00
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Wh 4 023 Structure

Product Overview

The aminopyrimidinyl carbamate StemoleculeTM WH-4-023 is a potent Src and LCK inhibitor (IC50< 10 nM).1 WH-4-023 has been shown to support the conversion to and maintenance of human naïve pluirpotent stem cells.2

Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

L: Stemfactor™ LIF, Human Recombinant (03-0016), and

A: Stemfactor™ Activin A, Human Recombinant (03-0001)


Product Specifications

Product Name                  

StemoleculeTM WH-4-023

Catalog Number              

04-0079

Size                                       

2 mg

Alternate Name              

2,6-dimethylphenyl 2,4-dimethoxyphenyl(2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)carbamate

Chemical Formula          

C32H36N6O4

Molecular Weight          

568.67

CAS Number                     

837442-57-8

Purity                                   

Greater than 99% purity by HPLC analysis

Appearance                      

Off-white to brown color solid

Solubility

This molecule is soluble in DMSO at 100 mM and in ethanol at 2.5 mM at room temperature.  For a 10 mM concentrated stock solution of WH-4-023, reconstitute the compound by adding 352 μL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37 C for 2 to 5 minutes. For cell culture, the media should be pre-warmed prior to adding the reconstituted compound. The maximum concentration recommended for dilution in media to ensure complete solubility is 10 μM. Note: for most cells, the maximum tolerance to DMSO is less than 0.5% by volume.

Storage and Stability

Store powder for up to six months at 4 C, protected from light. Following reconstitution, store aliquots at -20 C.

Quality Control                

The purity of WH-4-023 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry.  Cellular toxicity of WH-4-023 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets



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