Stemolecule™ SB590885

Catalog Size Price Quantity
04-0080 2 mg $79.00
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Product Overview

The triarylimidazole derivative StemoleculeTM SB590885 is a potent (KI,app<0.2 nM) for and selective (>10-fold selectivity against C-RAF) inhibitor of B-RAF kinase.1 SB590885 blocks MAPK activation, proliferation, transformation, and tumorigenicity of B-RAF-expressing malignant cells. SB590885 has been shown to support the conversion and maintenance of human naïve stem cells.2

Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

L: Stemfactor™ LIF, Human Recombinant (03-0016), and

A: Stemfactor™ Activin A, Human Recombinant (03-0001)


Product Specifications

Product Name

StemoleculeTM SB590885

Catalog Number

04-0080

Size

2 mg

Alternate Name

5-(2-(4-(2-Dimethylaminoethoxy)phenyl)-5-(4-pyridinyl)-1H-imidazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

Chemical Formula

C27H27N6O2

Molecular Weight

453.54

CAS Number

405554-55-4

Purity

>99% by HPLC analysis

Appearance

 Light yellow to yellow color solid

Solubility

SB590885 is soluble in DMSO at 100mL and in ethanol at 1mM at room temperature. For a 10mM concentrated stock solution of SB590885 in DMSO, reconstitute the compound by adding 441 uL of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37C for 2 to 5 minutes. For cell culture, the media should be pre-warmed prior to adding the reconstituted compound. The maximum concentration recommended for dilution in media to ensure complete solubility is 10uM. Note: for most cells, the maximum tolerance to DMSO is less than 0.5% by volume.

Storage and Stability

Store powder for up to six months at 4C, protected from light. Following reconstitution, store aliquots at -20C.

Quality Control

The purity of SB590885 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SB590885 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets



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