Stemolecule™ Y27632 Dihydrochloride Hydrate

Catalog Size Price Quantity
04-0012-H-10 10 mg $499.00
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Figure 1: Y27632 Dihydrochloride Hydrate Structure

Product Overview

Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. Y27632 in combination with Pifithrin-µ significantly improves cell recovery after cryopreservation4.

 
Also available: Stemolecule™ Y27632 (04-0012), Stemolecule™ Y27632 in Solution (04-0012-02)
 

Stemgent conveniently provides all the components comprising the 5i/L/A media supplment necessary to support naive pluripotent stem cell applications.

5i (inhibitors):

L: Stemfactor™ LIF, Human Recombinant (03-0016), and

A: Stemfactor™ Activin A, Human Recombinant (03-0001)


Product Specifications

Size

10 mg

Alternate Name

(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridine-4-yl)cyclohexanecarboxamide dihydrochloride hydrate

Chemical Formula

C14H21N3O・2HCl・H2O

Molecular Weight

338.27

CAS Number

331752-47-7

Purity

Greater than 98%

Formulation

White to pale yellow crystalline powder

Solubility

Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.

Storage and Stability

Store powder at -20 °C protected from light. Following reconstitution, store aliquots at -20 °C. Stock solutions are stable for 6 months when stored as directed.

Quality Control

The purity of Y27632 was determined by HPLC analysis.
Elemental analysis, NMR, mass spectrum: consistent with structure.
Cellular toxicity of Y27632 was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets

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