Stemolecule™ SHH Antagonist

Catalog Size Price Quantity
04-0032 2 mg $199.00
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04 0032 Figure 1

Product Overview

SHH Antagonist, also known as JK184 or Hh Signaling Antagonist VII, is a Sonic hedgehog (SHH) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition1. Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression2,3. Sonic hedgehog is the best studied ligand of the vertebrate pathway. One of the best studied examples is the action of Sonic hedgehog during development of the vertebrate limb, in which both the concentration and the time of exposure to SHH determines which digit into which the tissue will develop4.


Product Specifications

Size

2 mg

Alternate Name

JK184
Hh Signaling Antagonist VII
N-(4-ethoxyphenyl)-4-(2-methylimidazol[1,2-a]pyridine-3-yl)thiazol-2-amine

Chemical Formula

C19H18N4OS

Molecular Weight

350.44

CAS Number

315703-52-7

Purity

Greater than 99% by HPLC analysis

Formulation

Light pink color

Solubility

For a 10 mM concentrated stock solution of SHH Antagonist, reconstitute the compound by adding 570.7 μl of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For cell culture, the media should be prewarmed prior to adding the reconstituted compound. Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 100 mM.

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. 

Quality Control

The purity of SHH Antagonist was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SHH Antagonist was tested on mouse embryonic stem cells.


Specification Sheets

Safety Data Sheets

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