Stemolecule™ Wnt Inhibitor IWP-2

Catalog Size Price Quantity
04-0034 2 mg $99.00
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04 0034 Figure 1

Product Overview

Stemolecule Wnt Inhibitor IWP-2 was identified in a high throughput screen for antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1.  


Product Specifications

Size

2 mg

Alternate Name

N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2 d]pyrimidin-2-yl)thio]-acetamide

Chemical Formula

C22H18N4O2S3

Molecular Weight

466.6

CAS Number

686770-61-6

Purity

Greater than 99% by HPLC analysis 

Formulation

White powder

Solubility

For a 5 mM concentrated stock solution of Wnt Inhibitor IWP-2, reconstitute the compound by adding 857.3 µl of DMSO to the entire contents of the vial.  If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes.  For cell culture, the media should be prewarmed prior to adding the reconstituted compound.  Note: for most cells, the maximum tolerance to DMSO is less than 0.5%. This molecule is soluble in DMSO at 5 mM.

Storage and Stability

Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. 

Quality control

The purity of Wnt Inhibitor IWP-2 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of Wnt Inhibitor IWP-2 was tested on mouse embryonic stem cells. 

Related Products

  • Stemolecule™ Wnt Inhibitor IWP-4 (Cat.No.04-0036)
  • Stemolecule™ Wnt Inhibitor IWP-3 (Cat.No.04-0035)

Specification Sheets

Safety Data Sheets



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