Small Molecules for Stem Cell Research
Stemgent® offers a unique collection of small molecules, Stemolecules™, that can be used to dissect and modulate key signaling pathways involved in the self-renewal and differentiation of pluripotent stem cells, cellular reprogramming for the generation of induced pluripotent stem (iPS) cells, and induction and maintenance of the naïve state.
Stemolecules are stringently tested for high purity (≥98%), structurally verified by NMR and mass spectrometry, and tested for cytotoxicity on stem cells. View Product Sheet
Many Stemolecules are used routinely at ReproCELL to enhance iPS cell generation and maintain pluripotent stem cell cultures.
Mouse embryonic stem (ES) cells were maintained with 100 nM SC1 for 5 passages, fixed, and examined by immunocytochemistry for SSEA-1, Oct4 (shown here), Nanog, and Sox2. Results were comparable to cells maintained with 1000 units/ml LIF.